chimeric mice

Objective To study the spontaneous tumors derived in chimeric mice resulting from injection of embryonic stem ( ES) cells into host blastocysts.

目的观察胚胎干细胞（ES细胞）囊胚腔注射的方法构建嵌合体小鼠自发性肿瘤。

most cell lines maintained normal karyotype and expressed markers of pluripotency, including germline transmission in chimeric mice.

经ES细胞鉴定，结果表明大部分ES样细胞系保持正常的核型并表达多能性的标志分子，可以在嵌合体小鼠中进行生殖系传递。

the application of dna fingerprint technique in monitoring the es cell chimeric mice

DNA指纹图在小鼠ES细胞嵌合体鉴定中的应用

The Presentation of neo Gene in Chimeric Mice Obtained from ES Cells

通过胚胎干细胞途径获得的嵌合体小鼠中neo基因在各组织中的分布

establishment and determination of chimeric mice stably expressing green fluorescent protein

绿色荧光蛋白嵌合体小鼠的建立和鉴定

they also showed that conventional antiviral drugs could help clear the hepatitis infection in the chimeric mice.

他们的研究还显示传统的抗病毒药物有助于清除这些嵌合子小鼠的肝炎感染。

Methods We isolated embryonic stem cells from inner cell mass of KM mice blastocysts. Then we transferred embryonic stem cells into blastocoele of C57BL/ 6J inbred mice by microinjection in order to construct chimeric mice.

方法从KM小鼠囊胚的内细胞团中分离培养胚胎干细胞，进行近交系C57BL6J小鼠受体囊胚腔内注射，进行嵌合体构建实验。

however, these ips cells had a different global gene expression pattern from es cells and failed to produce adult chimeric mice.

然而，这些iPS细胞从胚胎干细胞有不同的整体基因表达模式，并没有产生嵌合小鼠成年。